Will Chantix make acid reflux worse?
Honest questions are hard to come by, and this is one of them. I can say that in my case, Chantix caused midsection pain, with increased reflux/heartburn. The fix was simple: different forms of antacids from the doctor who prescribed the Chantix. The same rules apply here, if the doctor gives you a medicine to take, it’s because there is no other option.

In the end, your stomach will feel better, as nicotine has a way of relaxing your lower sphincter of your esophagus. Once you are off nicotine, your reflux might actually go away! So stick to the path you’ve chosen. Your whole body will thank you soon for quitting, however unlikely it might seem now.

Remember, you’re now on 1 chemical, and off 4,000+ others. There is no comparison in the health benefits.